6/2/2023 0 Comments Girl outlineIn this study, we performed a sex-stratified genome-wide association analysis for broad depression with the UK Biobank total participants ( N = 274,141), including only non-related participants, as well as with males ( N = 127,867) and females ( N = 146,274) separately.īioinformatics analyses were performed to characterize common and sex-specific markers and associated processes/pathways. While genome-wide association studies (GWAS) adjust for sex differences, to date, no studies seek to identify sex-specific markers and pathways. There are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. Molecular PsychiatryĪ sex-specific genome-wide association study of depression phenotypes in UK Biobank “ A sex-specific genome-wide association study of depression phenotypes in UK Biobank” by Patrícia Pelufo Silveira et al. “In the clinic, the presentation of depression is very different for men and women, as well as their response to treatment, but we have very little understanding of why this happens at the moment.” About this genetics and depression research newsĬontact: Press Office – McGill University Patricia Pelufo Silveira, lead author and Associate Professor in the Department of Psychiatry. These findings are important to inform the development of specific therapies that will benefit both men and women while accounting for their differences,” says Dr. “This is the first study to describe sex-specific genetic variants associated with depression, which is a very prevalent disease in both males and females. The researchers found 11 areas of DNA that were linked to depression in females, and only one area in males. This information can be useful to identify future sex-specific treatments for depression. They also found that depression was specifically linked to metabolic diseases in females, an important aspect to consider when treating women with depression.ĭespite the biological processes involved in depression being similar in males and females, researchers found that different genes were involved for each sex. ![]() ![]() In a study of more than 270,000 individuals, the researchers found that sex-specific prediction methods were more accurate in forecasting an individual’s genetic risk of developing depression than prediction methods that did not specify sex. They also found depression was associated with metabolic disease in women, providing an important new aspect to consider when treating depressive symptoms.ĭepression is widely reported to be more common in women than in men, with women twice as likely to receive a diagnosis than men.Ī new sex-specific study from McGill University has found that there are differences between male and female genes and how they relate to depression. Summary: Researchers identified 11 areas of DNA that were linked to depression in women and one in males.
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